​​​​​(12) Mercer, J. A. M.*; DeCarlo, S. J.*; Roy Burman, S. S.*; Sreekanth, V.; Nelson, A. T.; Hunkeler, M.; Chen, P. J.; Donovan, K. A.; Kokkonda, P.; Tiwari, P. K.; Shoba, V. M.; Deb, A.; Choudhary, A.; Fischer, E. S.; Liu, D. R. Continuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues. Science 2024, 383, eadk4422. 10.1126/science.adk4422

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(11) Lee, G. R.; Pellock, S. J.; Norn, C.; Tischer, D.; Dauparas, J.; Anischenko, I.; Mercer, J. A. M.; Kang, A.; Bera, A.; Nguyen, H.; Goreshnik, I.; Vafeados, D.; Roullier, N; Han, H. L.; Coventry, B.; Haddox, H. K.; Liu, D. R.; Yeh, A. H.-W.; Baker, D. Small-molecule binding and sensing with a designed protein family. Preprint 10.1101/2023.11.01.565201

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(10) Nguyen, T. M.; Sreekanth, V.; Deb, A.; Kokkonda, P.; Tiwari, P. K.; Donovan, K. A.; Shoba, V.; Chaudhary, S. K.; Mercer, J. A. M.; Lai, S.; Sadagopan, A.; Jan, M.; Fischer, E. S.; Liu, D. R.; Ebert, B. L.; Choudhary, A. Proteolysis Targeting Chimeras With Reduced Off-Targets. Nat. Chem. 2024, 16, 218–228. 10.1038/s41557-023-01379-8

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(9) Anzalone, A. V.; Gao, X. D.; Podracky, C. J.; Nelson, A. T.; Koblan, L. W.; Raguram, A.; Levy, J. M.; Mercer, J. A. M.; Liu, D. R. Programmable Deletion, Replacement, Integration and Inversion of Large DNA Sequences with Twin Prime Editing. Nat. Biotechnol. 2022, 40 (5), 731–740. 10.1038/s41587-021-01133-w

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(8) Patel, S. C.; Smith, M. W.; Mercer, J. A. M.; Suzuki, K.; Burns, N. Z. Enantioselective Cyclobutenylation of Olefins Using N -Sulfonyl-1,2,3-Triazoles as Vicinal Dicarbene Equivalents. Org. Lett. 2021, 23 (16), 6530–6535. 10.1021/acs.orglett.1c02331

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(7) Chen, Z.; Zhu, X.; Yang, J.; Mercer, J. A. M.; Burns, N. Z.; Martinez, T. J.; Xia, Y. The Cascade Unzipping of Ladderane Reveals Dynamic Effects in Mechanochemistry. Nat. Chem. 2020, 12 (3), 302–309. 10.1038/s41557-019-0396-5

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(6) Su, J. K.; Feist, J. D.; Yang, J.; Mercer, J. A. M.; Romaniuk, J. A. H.; Chen, Z.; Cegelski, L.; Burns, N. Z.; Xia, Y. Synthesis and Mechanochemical Activation of Ladderene–Norbornene Block Copolymers. J. Am. Chem. Soc. 2018, 140 (39), 12388–12391. 10.1021/jacs.8b08908

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(5) Moss, F. R.; Shuken, S. R.; Mercer, J. A. M.; Cohen, C. M.; Weiss, T. M.; Boxer, S. G.; Burns, N. Z. Ladderane Phospholipids Form a Densely Packed Membrane with Normal Hydrazine and Anomalously Low Proton/Hydroxide Permeability. Proc. Natl. Acad. Sci. 2018, 115 (37), 9098–9103. 10.1073/pnas.1810706115

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(4) Chen, Z.; Mercer, J. A. M.; Zhu, X.; Romaniuk, J. A. H.; Pfattner, R.; Cegelski, L.; Martinez, T. J.; Burns, N. Z.; Xia, Y. Mechanochemical Unzipping of Insulating Polyladderene to Semiconducting Polyacetylene. Science 2017, 357 (6350), 475–479. 10.1126/science.aan2797

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(3) Mercer, J. A. M.; Cohen, C. M.; Shuken, S. R.; Wagner, A. M.; Smith, M. W.; Moss, F. R.; Smith, M. D.; Vahala, R.; Gonzalez-Martinez, A.; Boxer, S. G.; Burns, N. Z. Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid. J. Am. Chem. Soc. 2016, 138 (49), 15845–15848. 10.1021/jacs.6b10706

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(2) Seiple, I. B.; Mercer, J. A. M.; Sussman, R. J.; Zhang, Z.; Myers, A. G. Stereocontrolled Synthesis of Syn -β-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide. Angew. Chem. Int. Ed. 2014, 53 (18), 4642–4647. 10.1002/anie.201400928

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(1) Lajoie, M. J.; Rovner, A. J.; Goodman, D. B.; Aerni, H.-R.; Haimovich, A. D.; Kuznetsov, G.; Mercer, J. A. M.; Wang, H. H.; Carr, P. A.; Mosberg, J. A.; Rohland, N.; Schultz, P. G.; Jacobson, J. M.; Rinehart, J.; Church, G. M.; Isaacs, F. J. Genomically Recoded Organisms Expand Biological Functions. Science 2013, 342 (6156), 357–360. 10.1126/science.1241459